Synthesis of novel seco-acyclo-N-diazolyl-thione nucleosides analogous derived from acetic acid: characterization, complex formation with ions Pb(II), Hg(II) and antibacterial activity

Three diazoles namely 5-methyl-1,3,4-oxadiazole -2(3H)-thione, 5-methyl-1,3,4-thiadiazol-2(3H)-thione and 4-amino-5-methyl-2H-1,2,4-triazole-3-thiol were synthesized from acetic acid or ethyl acetate. Seco-acyclo-N-nucleoside analogous was by condensation of 1,3-benzylidine-glyceryl-2-tosylate with the three diazoles. Structural proof based upon IR, 1H-NMR, 13C-NMR spectroscopy MS measurements. The tendency to form complex between 1,3,4-oxadiazole 1,3,4-thiadiazoles Pb(II) Hg(II) ions achieved, their structures assigned observing some changes in physical properties such as, MP, coloration, Rf (TLC), IR UV spectroscopy. Most compounds tested vitro against Gram-positive Gram-negative bacteria showed variable activity. Hg2+ complexes oxadiazole thiadiazole derivatives exhibited appreciable antibacterial effect at lower MIC, compatible reference vancomycin. Similarly, oxadiazole-nucleoside high on bacteria.